Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity.
نویسندگان
چکیده
Betulin derivatives are a widely studied group of compounds of natural origin due to their wide spectrum of biological activities. This paper describes new betulin derivatives, containing a phosphonate group. The allyl-vinyl isomerization and synthesis of acetylenic derivatives have been reported. Structural identification of products as E and Z isomers has been carried out using ¹H-, (13)C-, (31)P-NMR, and crystallographic analysis. The crystal structure in the orthorhombic space group and analysis of crystal packing contacts for 29-diethoxyphosphoryl-28-cyclopropylpropynoyloxy-lup-20E(29)-en-3β-ol 8a are reported. All new compounds were tested in vitro for their antiproliferative activity against human T47D (breast cancer), SNB-19 (glioblastoma), and C32 (melanoma) cell lines.
منابع مشابه
Synthesis, structure and cytotoxic activity of new acetylenic derivatives of betulin.
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عنوان ژورنال:
- Molecules
دوره 21 9 شماره
صفحات -
تاریخ انتشار 2016